Milestone 1
Ethical approval of the protocol for animal studies
Milestone 2
Determination of empty SRMs biodistribution in vivo upon two administration methods (intravenous and intranasal) at different doses and time points.
Milestone 3
Dose-response evaluation of GALC-SRMs upon two administration methods (intravenous and intranasal). Selection of the best administration method.
Milestone 4
Acute and chronic toxicity evaluation of GALC-SRMs upon the selected administration method.
Milestone 5
Determination of optimized protocols for FS-SRMs production, characterization of their chemical-physical properties and dose-response testing in vivo upon two administration methods.
Milestone 6
Determination of protocols for scaling up the SRM production and for optimal storage.